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Criticism of the study on acid blockers

Online Medical Journal, 05.08.2019

  • Criticism of the study on acid blockers 2
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DGVS Comments

Do acid blockers actually promote allergies, as the authors of a recent study point out? German experts have doubts about the validity of the study.

BERLIN. The German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) sees no relationship between ingestion of gastric acid antagonists and the development of allergies, as is the case in a recent study (which we have reported). The study based on the data of the Austrian health insurance companies can not make any statement on the basis of their design and data situation if the inhibition of the acid favors the ## 147 ############################################################################ 39, appearance of allergies, criticizes the DGVS.

Several critics

Professor gastroenterologist Herbert Koop, former chief medical officer of the department of general internal medicine and gastroenterology of the HELIOS-Klinikum Berlin-Buch, has several critics, according to the press release of the DGVS.

On the one hand, the study looked at different drugs – sucralfates, which have virtually no influence on the pH of the stomach, H2Blockers, which are classified as moderately active acid inhibitors and proton pump inhibitors as strong acid inhibitors.

According to the study, all substances increase the risk of allergy. "Thus, there is no correlation with the degree of acid inhibition, so it is questionable whether the acid inhibition should be seen in relation to the 'Allergieentstehung,' said Koop in the message.

No data on allergy diagnoses

On the other hand, the analysis based on the Allergieentstehung only relies on the prescription of drugs meant to indicate the presence of an allergy. The data on allergy diagnoses themselves were not available.

This too is a weak point for Koop. Because, for example, drugs such as phenothiazines were included in the study, which are mainly used as neuroleptics in neurological and psychiatric diseases, would be prescribed only in individual cases of allergy.

Basically, the fact that a drug has been prescribed, is not suitable to draw the cause of other new diseases such as allergies here. Also in the study was not sufficiently distinguished, what allergies it was.

Confounding factors are not taken into account

In addition, according to Koop, additional patient information ("confounders") was not taken into account in the study. "It is scientifically proven that patients on PPIs, for example, differ considerably from other patients: they are generally older, have more comorbidities, are taking more drugs.This influence could not be assessed in the current study. published because the researchers obviously did not have access to such important data on the drug – or even better on diagnostic data – "said Koop in the communication of the DGVS.

The DGVS criticizes the fact that the publication does not unnecessarily disrupt patients whose confirmed indication of anti-acid treatment is confirmed. At the same time, the professional society stresses that patients must ensure that over-the-counter gastric acid inhibitors do not take them for long periods of time without consulting their family doctor. (Eb)

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Criticism of the study on acid blockers 6

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